Stiff person syndrome and other immune-mediated movement disorders – new insights

Stiff person syndrome, startle and other immune-mediated movement disorders – new insights

Eye movement abnormalities in stiff person syndrome.

The authors describe a 38-year-old woman with stiff person syndrome (SPS) and gaze-holding nystagmus, limited abduction, vertical and horizontal ocular misalignment, deficient smooth pursuit, and impaired saccade initiation. There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA.

[Stiff-person syndrome and other myelopathies constitute paraneoplastic neurological syndromes].

Stiff-person syndrome (SPS) is an autoimmune neurological disorder characterized by rigidity of the trunk and proximal limb muscles, intermittent superimposed spasms, and increased sensitivity to external stimuli. It has been more than 50 years since Moerch and Woltman reported the first 14 cases with this syndrome. During the last half century, many autoantibodies discovered, such as anti-glut...

Glycine receptor antibodies in stiff-person syndrome and other GAD-positive CNS disorders.

published online October 30, 2013 Neurology Harry Alexopoulos, Sofia Akrivou and Marinos C. Dalakas GAD-positive CNS disorders Glycine receptor antibodies in stiff-person syndrome and other This information is current as of October 30, 2013 html http://www.neurology.org/content/early/2013/10/30/01.wnl.0000436617.40779.65.full. located on the World Wide Web at: The online version of this article...

Stiff Person Syndrome.

Stiff-person syndrome or Moersch-Woltmann is a very rare and disabling neurologic disorder characterized by muscle rigidity and episodic spasms involving axial and limb musculature. It is an autoimmune disorder resulting in a malfunction of aminobutyric acid mediated inhibitory networks in the central nervous system. We describe a patient of stiff person syndrome.